Panthenol ( pantothenol)

General Information

Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5) and is thus a provitamin of B5. In organisms, it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.



Panthenol readily penetrates into the skin and mucous membranes (including the intestinal mucosa), where it is quickly oxidized to pantothenic acid.

Pantothenic acid is extremely hygroscopic,[4] that is, it binds water effectively. It is also used in the biosynthesis of coenzyme A, which plays a role in a wide range of enzymatic reactions and thus in cell growth.[2][3]



The Expert Panel released the Final Report on the Safety Assessment of Pantothenic Acid stating that Panthenol is safe as presently used in cosmetic products.


Key Therapeutic Benefits

In pharmaceuticals, cosmetics, and personal-care products, panthenol is a moisturizer and humectant, used in ointments, lotions, shampoos, nasal sprays, eye drops, lozenges, and cleaning solutions for contact lenses. In ointments, it is used for the treatment of sunburns, mild burns, minor skin injuries and disorders (in concentrations of up to 2–5%).[2]

It improves hydration, reduces itching and inflammation of the skin, improves skin elasticity, and accelerates epidermal wounds’ rate of healing.[3] For this purpose, it is sometimes combined with allantoin. stimulates the wound-healing , very good moisturizing properties , anti-inflammatory and anti-irritation , humectant for hair , strong deposition onto the cuticula, makes the hair easier to comb, glossy hair, deep penetration into the hair cortex, strengthens the hair shaft, penetrates the scalp and provide the hair roots with Pantothenic Acid, increase the water retention of the keratin structure of the nails, improves flexibility and stability of nails.


Used in  Orgado



  1. “Dexpanthenol – Compound summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 29 June 2012.
  2. ^ Jump up to: ab c Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Bepanthen Creme.
  3. ^ Jump up to: ab c Ebner F, Heller A, Rippke F, Tausch I (2002). “Topical Use of Dexpanthenol in Skin Disorders”. American Journal of Clinical Dermatology. 3 (6): 427–433. doi:2165/00128071-200203060-00005PMID 12113650.